LYMPHOID NEOPLASIA miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma
نویسندگان
چکیده
1Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; 2Department of Hematology, Juntendo Urayasu Hospital, Chiba, Japan; 3Department of Human Pathology and 4Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan; 5Department of Medical Genomics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; and 6Division of Functional Genomics, Jichi Medical University, Tochigi, Japan
منابع مشابه
miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.
Many transformed lymphoma cells show immune-phenotypes resembling the corresponding normal lymphocytes; thus, they provide a guide for proper diagnosis and present promising routes to improve their pathophysiologic understanding and to identify novel therapeutic targets. However, the underlying molecular mechanism(s) of these aberrant immune-phenotypes is largely unknown. Here, we report that m...
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Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic features and the consistent expression of CD30. It then became evident that the majority of these tumors are derived from lymphoid cells of T or null immunophenotype. The subsequent finding that t(2;5)(p23;q35) occurs in 40% to 60% of ALCL patients established a distinct clinicopathologic entity. This chr...
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Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic features and the consistent expression of CD30. It then became evident that the majority of these tumors are derived from lymphoid cells of T or null immunophenotype. The subsequent finding that t(2;5)(p23;q35) occurs in 40% to 60% of ALCL patients established a distinct clinicopathologic entity. This chr...
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